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High Quality Pharmaceutical Intermediate Inhibitors ISRIB trans-isomer CAS 1597403-47-8 ISRIB

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    CAS号码 #: 1597403-47-8 (trans-ISRIB)纯度 ≥98% Description: ISRIB, the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM. ISRIB reversed the effects of eIF2α phosphorylation with IC50 value of 5 nM.

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    CAS号码 #: 1597403-47-8 (trans-ISRIB)纯度 ≥98% Description: ISRIB, the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM. ISRIB reversed the effects of eIF2α phosphorylation with IC50 value of 5 nM.

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    Search results for trans-1,4-cyanocyclohexane at Sigma-Aldrich. Compare Products: Select up to 4 products. *Please select more than one item to compare

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    trans-ISRIB, the trans-isomer of ISRIB, is a symmetric bis-glycolamide that inhibits integrated stress response (ISR). In wild-type mice studies has shown that it improved memory by efficiently reversing the effects of eIF2α phosphorylation, which has brought expectation that inhibition of PERK signaling may have the potential to ameliorate Alzheimer's disease.

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  • ISRIB (trans-isomer) (CAS 1597403-47-8) (ab273604) |

    CAS号码 #: 1597403-47-8 (trans-ISRIB)纯度 ≥98% Description: ISRIB, the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM. ISRIB reversed the effects of eIF2α phosphorylation with IC50 value of 5 nM.

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  • ISRIB (trans-isomer) (CAS 1597403-47-8) (ab273604) |

    MW 451.34, Purity > 96%. Potent and selective PERK inhibitor with IC50 of 5 nM. Integrated stress response (ISR) inhibitor.

    Get Price
  • CAS 1597403-47-8 trans-ISRIB - BOC Sciences

    trans-ISRIB, the trans-isomer of ISRIB, is a symmetric bis-glycolamide that inhibits integrated stress response (ISR). In wild-type mice studies has shown that it improved memory by efficiently reversing the effects of eIF2α phosphorylation, which has brought expectation that inhibition of PERK signaling may have the potential to ameliorate Alzheimer's disease.

    Get Price
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    Used trans-ISRIB to inhibit the integrated stress response (ISR) in HEK293 cells. Induced the ISR and added ISRIB (100 and 500nM) overnight. Evaluated p-eif2a (unchanged) and cleaved caspase 3 (increased in a dose-dependent manner with ISRIB.

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    2020-11-20 · 483.47. 75 50 10 367.8. 76 50 10 263.2. 77 50 10 351.31. 78 50 10 281.98. 79 50 10 163.13. 80 50 10 318.14. 81 50 10 455.4. 82 50 10 262.22000000000003. 83 50 10 ... Esomeprazole Magnesium is the S-isomer of omeprazole, can reduce gastric acid secretion with selective and irreversible proton pump inhibitor activity.Esomeprazole magnesium acts ...

    Get Price
  • Neurological Disease (Inhibitors Agonists Modulators ...

    1597403-47-8 99.37% ISRIB (trans-isomer) is a potent inhibitor of PERK with an IC 50 of 5 nM.

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  • Alpha Lifetech

    Droxinostat (CMH, 5809354) is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47μM and 1.46 μM, greater than 8-fold selective against HDAC3 and no inhibition to HDAC1, 2, 4, 5, 7, 9, and 10. C11H14ClNO3 95635-56-6 Ranolazine 2HCl, is an antianginal medication. C24H35Cl2N3O4 135062-02-1 Potassium Channel

    Get Price
  • MedChemExpress (MCE): Inhibitors, Agonists & Screening ...

    YYA-021 is a small-molecule CD4 mimic that inhibits HIV entry, with high anti-HIV activity and low cytotoxicity. 317.4259 C18H27N3O2 10 mM in DMSO Infection B05 HY-10004 Faropenem daloxate 141702-36-5 Antibacterial; Faropenem medoxil Faropenem daloxate is the first oral penem in a new class of beta-lactam antibiotics. IC50 Value: Target ...

    Get Price